Atelier Ayesha ~Tasogare no Daich...アーシャのアトリエ ～黄昏の大地の錬金術士～

Atelier Ayesha: The Alchemist of Twilight Land is a Japanese role-playing video game developed by Gust. The character designs are by Hidari.

Atelier Ayesha stars a lonely girl who runs an alchemy studio. After her grandfather died, Ayesha’s younger sister Nio disappeared when she was gathering herbs. One day, Ayesha sees Nio walking through ruins which starts her journey. Overcoming sadness is one of the game’s themes and players will see Ayesha grow as she writes diary entries.
Atelier Ayesha takes place in a new world separate from the Arland saga where the art of alchemy is out of style. Most people forgot about it and Ayesha lives in an ever changing world.